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The new millennium has seen a resurgence in our appreciation of metabolism as a central discipline in our understanding of human health and disease. Although the pathways necessary for ATP production and synthesis of macromolecules (nucleic acids, lipids, and amino acids) were elucidated decades ago, their role in determining cell fate or function has been uncovered only recently. The discovery that oncogenes and tumour suppressors reprogram nutrient uptake and metabolism in malignant cells has re-energized the field of cancer metabolism and more broadly stimulated a second “golden age” of disease-oriented research in biochemistry. Recent work has also shown that metabolites themselves influence signal transduction and gene expression, indicating a surprising degree of crosstalk between metabolism and other regulatory networks in cells and tissues. Metabolites are also important in communication between cells both within a tissue and systemically throughout the body. At this conference we will discuss the role of metabolism in controlling cell fate and function in multiple contexts including cancer, tissue regeneration, immune responses and aging.